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Hepatic veno-occlusive disease : ウィキペディア英語版 | Hepatic veno-occlusive disease
Hepatic veno-occlusive disease or veno-occlusive disease (VOD) is a condition in which some of the small veins in the liver are obstructed. It is a complication of high-dose chemotherapy given before a bone marrow transplant (BMT) and is marked by weight gain due to fluid retention, increased liver size, and raised levels of bilirubin in the blood. The name sinusoidal obstruction syndrome is now preferred if VOD happens as a result of chemotherapy or bone marrow transplantation.〔 Apart from chemotherapy, VOD may also occur after ingestion of certain plant alkaloids such as pyrrolizidine alkaloids (in some herbal teas),〔 and has been described as part of a rare hereditary disease called ''hepatic venoocclusive disease with immunodeficiency'' (which results from mutations in the gene coding for a protein called SP110). ==Signs and symptoms== Features of VOD include weight gain, tender hepatomegaly, ascites, and increased bilirubin. It often is associated with renal failure.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Hepatic veno-occlusive disease」の詳細全文を読む
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